Published:
International journal of obesity and related metabolic disorders
Date:
Abstract:
Leptin resistance is a hallmark of obesity, but its etiology is unknown,
and its clinical measurement is elusive. Leptin-sensitive subjects have
normal resting energy expenditure (REE) at a low leptin concentration,
while leptin-resistant subjects have a normal REE at a higher leptin
concentration; thus, the ratio of REE:Leptin may provide a surrogate index
of leptin sensitivity.