Factors Affecting Hemoglobin A1C in the Diagnosis of Diabetes and Prediabetes in Youth

Published: Journal of Pediatric Nursing
Date:
Authors: Jennifer McGuire Hitt 1 , Pedro Velasquez-Mieyer 2 , Claudia Neira 2 , Patricia Cowan 3
Abstract:
We sought to examine the correlation between variables and A1C levels to determine if prediction modeling could be used in the screening and diagnosis of diabetes and prediabetes in youth. We also sought to test relationships between A1C levels to insulin sensitivity indices and β-cell function indices. Design and methods: We performed a retrospective review of 904 medical records from youth deemed at-risk for the disease.

Diabetes Care in Venezuela

Published: Annals of Global Health
Date:
Authors: Ramfis Nieto-Martínez 1 , Juan P González-Rivas 2 , Marcos Lima-Martínez 3 , Victoria Stepenka 4 , Alejandro Rísquez 5 , Jeffrey I Mechanick 6
Abstract:
The incidence of type 2 diabetes (T2D) and its economic burden have increased in Venezuela, posing difficult challenges in a country already in great turmoil.

Transcultural diabetes nutrition algorithm (tDNA): Venezuelan application

Published: Nutrients
Date:
Authors: Ramfis Nieto-Martínez 1 , Osama Hamdy 2 , Daniel Marante 3 , María Inés Marulanda 4 , Albert Marchetti 5 , Refaat A Hegazi 6 , Jeffrey I Mechanick 7
Abstract:
Medical nutrition therapy (MNT) is a necessary component of comprehensive type 2 diabetes (T2D) management, but optimal outcomes require culturally-sensitive implementation.

A pilot study of QT interval analysis in overweight and obese youth

Published: Applied Nursing Research
Date:
Authors: Shirleatha Lee 1 , Patricia Ann Cowan, Pedro Velasquez-Mieyer
Abstract:
This descriptive pilot study examined if manual corrected QT (QTc) interval measures obtained from a standard 12-lead electrocardiogram (ECG) correlated with automated 24-hour ambulatory Holter QTc measures in 30 overweight and obese youth aged 12-17 years.

Prediabetes and blood pressure effects on heart rate variability, QT-interval duration, and left ventricular hypertrophy in overweight-obese adolescents

Published: The Journal of Pediatric Nursing
Date:
Authors: Shirleatha Lee 1 , Patricia Ann Cowan, Glenn T Wetzel, Pedro Velasquez-Mieyer
Abstract:
This ancillary, descriptive correlational study examined the effect of glucose regulation, blood pressure (BP), and their combined effects on cardiac autonomic function in 128 overweight-obese 11-18-year-olds.

Racial disparity in glucagon-like peptide 1 and inflammation markers among severely obese adolescents

Published: Diabetes Care
Date:
Authors: Pedro A Velásquez-Mieyer 1 , Patricia A Cowan, Sylvia Pérez-Faustinelli, Ramfis Nieto-Martínez, Cesar Villegas-Barreto, Elizabeth A Tolley, Robert H Lustig, Bruce S Alpert
Abstract:
Compared with Caucasians, obese African-American adolescents have a higher risk for type 2 diabetes. Subclinical inflammation and reduced glucagon-like peptide 1 (GLP-1) concentration are linked to the pathogenesis of the disease.

Metabolic syndrome: from global epidemiology to individualized medicine

Published: Clinical Pharmacology & Therapeutics
Date:
Authors: J A Batsis 1 , R E Nieto-Martinez, F Lopez-Jimenez
Abstract:
The metabolic syndrome (MetS) encompasses a constellation of metabolic abnormalities that are thought to place patients at higher risk for the development of diabetes and cardiovascular (CV) disease.

Obesity and cardiometabolic syndrome in children

Published: Therapeutic Advances in Cardiovascular Disease
Date:
Authors: Pedro Velasquez-Mieyer 1 , Claudia P Neira, Ramfis Nieto, Patricia A Cowan
Abstract:
The cardiometabolic syndrome is highly prevalent among overweight youth. The risk of developing the cardiometabolic syndrome is likely triggered or exacerbated by concurrent obesity, unhealthy lifestyle/eating habits, and hormonal changes (puberty).

Insulin dynamics predict body mass index and z-score response to insulin suppression or sensitization pharmacotherapy in obese children

Published: The Journal of Pediatrics
Date:
Authors: Robert H Lustig 1 , Michele L Mietus-Snyder, Peter Bacchetti, Ann A Lazar, Pedro A Velasquez-Mieyer, Michael L Christensen
Abstract:
To assess the use of oral glucose tolerance testing (OGTT) to predict efficacy of insulin sensitization (metformin) or suppression (octreotide) because insulin resistance and insulin hypersecretion may impact pharmacotherapeutic efficacy in obese children.

Single- and multiple-dose pharmacokinetics of pioglitazone in adolescents with type 2 diabetes

Published: The Journal of Clinical Pharmacology
Date:
Authors: Michael L Christensen 1 , Bernd Meibohm, Edmund V Capparelli, Pedro Velasquez-Mieyer, George A Burghen, William V Tamborlane
Abstract:
This study assessed the single- and multiple-dose pharmacokinetics of 3 doses (15 mg, 30 mg, and 45 mg) of pioglitazone in 36 adolescents with type 2 diabetes.