Factors Affecting Hemoglobin A1C in the Diagnosis of Diabetes and Prediabetes in Youth

Published: Journal of Pediatric Nursing
Date:
Authors: Jennifer McGuire Hitt 1 , Pedro Velasquez-Mieyer 2 , Claudia Neira 2 , Patricia Cowan 3
Abstract:
We sought to examine the correlation between variables and A1C levels to determine if prediction modeling could be used in the screening and diagnosis of diabetes and prediabetes in youth. We also sought to test relationships between A1C levels to insulin sensitivity indices and β-cell function indices. Design and methods: We performed a retrospective review of 904 medical records from youth deemed at-risk for the disease.

Transcultural diabetes nutrition algorithm (tDNA): Venezuelan application

Published: Nutrients
Date:
Authors: Ramfis Nieto-Martínez 1 , Osama Hamdy 2 , Daniel Marante 3 , María Inés Marulanda 4 , Albert Marchetti 5 , Refaat A Hegazi 6 , Jeffrey I Mechanick 7
Abstract:
Medical nutrition therapy (MNT) is a necessary component of comprehensive type 2 diabetes (T2D) management, but optimal outcomes require culturally-sensitive implementation.

A multicenter, randomized, double-blind, placebo-controlled, dose-finding trial of a long-acting formulation of octreotide in promoting weight loss in obese adults with insulin hypersecretion

Published: International Journal of Obesity
Date:
Authors: R H Lustig 1 , F Greenway, P Velasquez-Mieyer, D Heimburger, D Schumacher, D Smith, W Smith, N Soler, G Warsi, W Berg, J Maloney, J Benedetto, W Zhu, J Hohneker
Abstract:
Objective: To compare changes in weight in obese patients who received long-acting octreotide (octreotide LAR) at one of three dose levels (20, 40, or 60 mg) or placebo over 6 months and to identify the lowest dose of octreotide LAR that safely achieved optimal weight loss.

Type 2 diabetes mellitus in children and adolescents: the new challenge

Published: Journal of Pediatric Pharmacology and Therapeutics
Date:
Authors: Michael L Christensen 1 , Sahar M Rashed, Julie Sinclair, Patricia A Cowan, Pedro Velasquez-Mieyer, George A Burghen
Abstract:
The epidemic increase in the incidence of type 2 diabetes mellitus (T2DM) in children and adolescents is presenting enormous challenges to the medical profession. The combination of factors such as obesity, ethnicity, puberty, and genetic predisposition has contributed to the development of T2DM in younger ages.

Hypothalamic obesity caused by cranial insult in children: altered glucose and insulin dynamics and reversal by a somatostatin agonist

Published: The Journal of Pediatrics
Date:
Authors: R H Lustig 1 , S R Rose, G A Burghen, P Velasquez-Mieyer, D C Broome, K Smith, H Li, M M Hudson, R L Heideman, L E Kun
Abstract:
Hypothalamic obesity is a rare sequela of cranial insult, for which pathogenesis and treatment remain obscure. In rodents ventromedial hypothalamic damage causes hyperphagia, obesity, hyperinsulinism, and insulin resistance. Reduction of insulin secretion in humans may attenuate weight gain.